Capex

Capex

(Capecitabine)

Composition:

Each film-coated tablet contains 150mg capecitabine
Each film-coated tablet contains 500mg capecitabine

ATC Code

L01BC06- Capecitabine

Structure

Description

Capecitabine is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5’-deoxy-5-fluorouridine (5’-DFUR) which is converted to 5-fluorouracil. The chemical name for capecitabine is 5’-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytine.

Indication

Associated Conditions

Pharmacodynamics

Absorption
Readily absorbed through the GI tract (~70%)

Peak Plasma Time
1.5 hr (capecitabine); 2 hr (5-FU)

Protein binding
Protein bound: <60% (primary to albumin ~35%)

Metabolism
Metabolized by thymidine phosphorylase to fluoruracil.

Hover over products below to view reaction partners
Capecitabine 5’-Deoxy-5-fluorouridine 5-fluorouracil

Route of elimination
Capecitabine and its metabolites are predominantly excreted in urine; 95.5% of administered capecitabine dose is recovered in urine. Fecal excretion is minimal (2.6%). The major metabolite excreted in urine is FBAL which represents 57% of the administered dose.About 3% of the administered dose is excreted in urine as unchanged drug.

Half-life
0.75 hr (parent capecitabine and 5-FU)

Mechanism of Action

Fluoropyrimidine carbamate with antineoplastic activity; it is a prodrug of 5’-deoxy-5-fluorouridine (F’-DFCR), which is then converted to 5-fluorouracil (5-FU)

Both normal and tumor cells metabolize 5-FU to 5-fluoro-2’-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP)

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